Endoscopic Injection Sclerotherapy(EIS) is currently the primary treatment of choice for the majority of patients who present esophageal vsarix bleeding. But, in EIS, unanswered methodologic problem and controversies remain. We assigned 99 patients with esophageal varix bleeding seen at Chungnam National University Hospital from May. 1989 to Dec. 1991. Single injection at one varix column was made in 73 patients (Mono-puncture group) and multiple injections were made in 26 patients (Multi-punctures group).
The results are follows
1) Mean age was 48.0±11.4 years and male to female ratio was 7：1, but there was no difference between 2 groups.
2) Most frequent etiology of bleeding varices were alcoholic liver cirrhosis(43％) and hepatitis B virus associated liver cirrhosis(31％), and the most patients had a advanecd liver disease, such as Child’s classification B(46％) and C(29％), but there was no difference between 2 groups.
3) In variceal form, rates of F1, F2 & F3 were 2％, 27％, & 67％, and red color sign was seen in 80％ of patients, but there was no difference between 2 groups.
4) Total number of treatment were 3.1±2.1 in mono-puncture group and 4.1±3.0 in multi-puncture group, and total volumes of sclerosant were 21.3±17.0ml, 30.3±19.4ml. Mean volumes per treatment session was 6.9±4.5ml, 7.4±5.9ml, and mean volume per one puncture site were 1.6±1.0ml and 1.1±0.9ml. There were significantly difference between 2 groups in total volume of sclerosant and mean volume per one puncture site.
5) Before and after EIS, the changes of hematologic finding were not significant, and transfusion requirments were decreased, in both groups.
6) Complications of EIS were chest and epigastric pain(82％), fever(31％), pleural effusion(8％), sclerotherapy failure(9％) and rebleeding during admission(15％), but there was no difference between 2 groups.
These findings suggest that differences of clinical effects and complications were not significant between 2 groups.
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